A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

This book covers the current state of knowledge of the adenosine A3 receptor. Coverage includes data from studies of theoretical, molecular, and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications.

This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor. It covers a wide range of information, including data from 3 studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available. Although the A receptor is increasingly being recognized for 3 its increasing number of biological roles throughout the body and many A receptor 3 ligands have proven useful in elucidating peripheral and central pathologies, many issues remain unresolved. Moreover, research activity in this field continues to grow exponentially, resulting in a constant flow of new information. The chapters in this book cover both basic science and the relevant applications and provide an authoritative account of the current status of the field. They have enabled my goal as editor to make A Adenosine Receptors from Cell Biology to Pharmacology and 3 Therapeutics an up to date, scientifically excellent, reference source, attractive to basic and clinical scientists alike, a reality. Detailed understanding of the physico-chemical aspects and molecular biology of the A receptor provides a solid basis for its future development as a target for 3 adenosine-based pharmacotherapies (Chapters 2 and 3).

Inhalt
From Hypertension (+) to Asthma: Interactions with the Adenosine A3 Receptor from a Personal Perspective.- Physico-chemical Properties and Molecular Biology.- Thermodynamic Analysis in DrugReceptor Binding: The A3 Adenosine Receptor.- Pharmacology and Molecular Biology of A3 Adenosine Receptors.- Signal Transduction.- Regulation of Second Messenger Systems and Intracellular Pathways.- The Desensitisation as A3 Adenosine Receptor Regulation: Physiopathological Implications.- Medicinal Chemistry.- A3 Adenosine Receptor Agonists: History and Future Perspectives.- A3 Adenosine Receptor Antagonists: History and Future Perspectives.- Molecular Modeling and Reengineering of A3 Adenosine Receptors.- Effects on Tissues and Organs and Therapeutic Applications.- Adenosine A3 Receptor Signaling in the Central Nervous System.- Cardiovascular Biology of the A3 Adenosine Receptor.- A3 Adenosine Receptor in the Pulmonary System.- A3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation.- Adenosine A3 Receptors in Muscle Protection.- A3 Adenosine Receptors, HIF-1 Modulation and Atherosclerosis.- Inflammatory and Auto-Immune Diseases.- Rheumatoid Arthritis: History, Molecular Mechanisms and Therapeutic Applications.- Cancer.- Agonists and Antagonists: Molecular Mechanisms and Therapeutic Applications.