Aberrant Cell Biology in Cystic Fibrosis Cells

This book describes a novel cell biological basis
contributing to aberrant innate immunity and
inflammation in the cystic fibrosis (CF) respiratory
tract. The first aspect covered involves the basis
for previously described hyperacidification of
organelles in CF cells, and how this phenomenon can
be pharmacologically corrected. The second aspect
focuses on the excessive production of a molecule
named Sialyl-Lewis X (Slx) in CF cells. Slx acts as
a receptor for neutrophils which cause excessive
damage in the CF bronchial epithelia. The third
aspect involves the discovery of attenuated
polymeric IgA transcytosis in CF cells, which may
contribute to excessive colonization of P.
aeruginosa. Future directions addressing these
aspects of the cell biology of CF are outlined.

Autorentext

Dr. Fazio received his Ph.D. in Biomedical Sciences from the University of New Mexico in December of 2007. His studies focussed on the cell biology and immunology of cystic fibrosis respiratory epithelial cells. Dr. Fazio makes his home in Albuquerque, New Mexico, USA.

Klappentext

This book describes a novel cell biological basis contributing to aberrant innate immunity and inflammation in the cystic fibrosis (CF) respiratory tract. The first aspect covered involves the basis for previously described hyperacidification of organelles in CF cells, and how this phenomenon can be pharmacologically corrected. The second aspect focuses on the excessive production of a molecule named Sialyl-Lewis X (Slx) in CF cells. Slx acts as a receptor for neutrophils which cause excessive damage in the CF bronchial epithelia. The third aspect involves the discovery of attenuated polymeric IgA transcytosis in CF cells, which may contribute to excessive colonization of P. aeruginosa. Future directions addressing these aspects of the cell biology of CF are outlined.