Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

Cellcell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins interact to assemble AJs and mediate adhesion?
• How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
• How do AJs affect cell behaviour and multicellular development?
• How can abnormal AJ activity lead to disease?

Up-to-date reviews of adherens junction biology from internationally recognized experts in the field Covers adherens junction biology from atoms to overall animal development and disease A comprehensive resource for the research laboratory A comprehensive teaching tool for advanced undergraduate and graduate courses in cell and developmental biology Valuable for both newcomers and experts in the field Includes supplementary material: sn.pub/extras

Inhalt

1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease. - Part I: How AJs evolved. - 2. Evolution of the cadherin-catenin complex. - Part II: How cadherins and catenins interact to assemble AJs. - 3. The three-dimensional structure of the cadherin-catenin complex. - 4. Biophysics of cadherin adhesion. - 5. Adherens junction assembly. - Part III: How AJs interface with other cellular machinery. - 6. The cytoskeleton and classical cadherin adhesions. - 7. Immunoglobulin superfamily receptors and adherens junctions. - 8. Signaling from the adherens junction. - 9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling. - Part IV: How AJs affect cell behaviour and multicellular development. - 10. Adherens junctions during cell migration. - 11. Adherens junctions and cadherins in Drosophila development. - 12. Adherens junctions in C. elegans embryonic morphogenesis. - 13.Cadherin function during Xenopus gastrulation. - 14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice. - Part V: How AJs affect tissue homeostasis and disease. - 15. Adherens junctions and stem cells. - 16. Adherens junctions and cancer. - 17. Adherens junctions and pathogens entry.