Adhesion Molecules: Function and Inhibition

Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided.

The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.

Relevant leukocyte and endothelial adhesion molecules are discussed Written by leaders in the field Provides outlook on future therapies Includes supplementary material: sn.pub/extras

Inhalt
Capture and rolling.- P-selectin glycoprotein ligand-1 (PSGL-1).- L-selectin-mediated leukocyte adhesion and migration.- P- and E-selectin.- Firm adhesion.- Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment.- ?4-integrins: structure, function and secrets.- VCAM-1 and its functions in development and inflammatory diseases.- Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function.- Transendothelial migration.- PECAM: Regulating the start of diapedesis.- Role of ?6?1 integrin in leukocyte adhesion and transmigration.- Vascular adhesion protein-1 (VAP-1).- The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues.- Structure and function of JAM proteins.- Promises and limitations of targeting adhesion molecules for therapy.