Advances in computational protein design

Protein design is the art of choosing an amino acid
sequence that will fold into a
desired structure. Computational protein design aims
to quantify and automate this
process. In computational protein design, various
metrics may be used to calculate an
energy score for a sequence with respect to a desired
protein structure. An ongoing
challenge is to find the lowest-energy sequences from
amongst the vast multitude of
sequence possibilities. A variety of exact and
approximate algorithms may be used in this
search.

Autorentext
Geoffrey Hom grew up in California. After completing his Ph.D., Geoff did a postdoc studying the genetics of the disease lupus. Geoff is currently exploring computer programming, with an emphasis on non-profit educational software developed in ActionScript 3.0.

Klappentext
Protein design is the art of choosing an amino acid sequence that will fold into a desired structure. Computational protein design aims to quantify and automate this process. In computational protein design, various metrics may be used to calculate an energy score for a sequence with respect to a desired protein structure. An ongoing challenge is to find the lowest-energy sequences from amongst the vast multitude of sequence possibilities. A variety of exact and approximate algorithms may be used in this search.