AMIDIN: Synthesis and investigation of its anti-diabetic properties

In the present study, we synthesized N-Ethyl-N'-(4H-1,2,4-triazol-3-yl) ethanamidine. We subsequently tried to test the action of amidine 2 at different doses ranging from 0.1mg to 0.4mg/kg bw on glucose-induced hyperglycemia in mice by comparing this effect with that of MetF a standard molecule. Starch significantly reduced blood glucose levels in normal and subacute hyperglycemic mice by glucose administration. In this context, we showed an increase in lipid peroxidation and a decrease in thiol groups.These alterations are accompanied by a reduction in antioxidant power. This protective action of the tested molecule would be essentially linked to its antioxidant activity and its action of improvement of the antioxidant enzymes. Starch induced a significant decrease of the concentration of glucose in blood and protected against the loss of body weight after a duration of treatment 30 days in mice made diabetic by alloxane, a very important diabetogenic chemical product

Autorentext

Dr. Azhar HAJRIDoutor em química orgânica (química dos heterócitos).Professor assistente na ISB Béja, Universidade de Jendouba, Tunísia

Klappentext

In the present study, we synthesized N-Ethyl-N -(4H-1,2,4-triazol-3-yl) ethanamidine. We subsequently tried to test the action of amidine 2 at different doses ranging from 0.1mg to 0.4mg/kg bw on glucose-induced hyperglycemia in mice by comparing this effect with that of MetF a standard molecule. Starch significantly reduced blood glucose levels in normal and subacute hyperglycemic mice by glucose administration. In this context, we showed an increase in lipid peroxidation and a decrease in thiol groups.These alterations are accompanied by a reduction in antioxidant power. This protective action of the tested molecule would be essentially linked to its antioxidant activity and its action of improvement of the antioxidant enzymes. Starch induced a significant decrease of the concentration of glucose in blood and protected against the loss of body weight after a duration of treatment 30 days in mice made diabetic by alloxane, a very important diabetogenic chemical product