Analysis of Complex Disease Association Studies

Genetics and genomic studies are changing the practice of medicine and public health and playing central roles in all biomedical sciences. This book provides researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests are highlighted and a critical analysis of the advantages and disadvantages, supplemented by case studies for each, provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available.

Provides researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools effectively. This book also provides readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests.

Inhalt

Chapter 1 Genetic architecture of complex disease
Chapter 2 Population genetics and linkage disequilibrium
Chapter 3 Genetic association study design
Chapter 4 Selection of SNPs
Chapter 5 Genotype calling
Chapter 6 Data handling
Chapter 7 Data quality control
Chapter 8 Single-locus tests of association for population-based studies
Chapter 9 Population structure
Chapter 10 Haplotype-based methods
Chapter 11 Interaction analyses
Chapter 12 Copy number variant analysis
Chapter 13 Analysis of family-based association studies
Chapter 14 Bioinformatics approaches
Chapter 15 Interpreting association signals
Chapter 16 Delineating association signals
Chapter 17 Case study: obesity
Chapter 18 Case study: rheumatoid arthritis