Analysis of Quantal Response Data

Zusatztext "This book is a welcome addition to the analysis of dose-response quantal bioassays which are so important in toxicology and pharmacology...it contdains the best collection and description of all known methods in bioassays."-Short Book Reviews of the ISI"...a thorough and readable reference..."-Technometrics"I believe that this book should be in the library of all applied statisticians...an excellent reference. It serves as a model for books on statistical methods in special areas and is a worthy successor to Finney's work! which has dominated the field for so long."-Journal of the American Statistical Association Informationen zum Autor Morgan, Byron J.T. Klappentext This book describes the new developments for the analysis of quantal response data, and emphasizes the links between the various different areas. The main emphasis in the examples which illustrate the methodology will be on the evaluation and testing of substances, mainly drugs, for use in humans. Zusammenfassung This book describes the new developments for the analysis of quantal response data, and emphasizes the links between the various different areas. The main emphasis in the examples which illustrate the methodology will be on the evaluation and testing of substances, mainly drugs, for use in humans. Inhaltsverzeichnis 1. Data, preliminary analyses and mechanistic models 2. Maximum-likelihood fitting of simple models 3. Extensions and alternatives 4. Extended models for quantal assay data 5. Describing time to response 6. Over-dispersion 7. Non-parametric and robust methods 8. Design and sequential methods

Autorentext
Morgan, Byron J.T.

Klappentext

This book takes the standard methods as the starting point, and then describes a wide range of relatively new approaches and procedures designed to deal with more complicated data and experiments - including much recent research in the area. Throughout mention is given to the computing requirements - facilities available in large computing packages like BMDP, SAS and SPSS are also described.

Zusammenfassung
This book describes the new developments for the analysis of quantal response data, and emphasizes the links between the various different areas. The main emphasis in the examples which illustrate the methodology will be on the evaluation and testing of substances, mainly drugs, for use in humans.

Inhalt

1. Data, preliminary analyses and mechanistic models 2. Maximum-likelihood fitting of simple models 3. Extensions and alternatives 4. Extended models for quantal assay data 5. Describing time to response 6. Over-dispersion 7. Non-parametric and robust methods 8. Design and sequential methods