Analysis of Some Phosphorus Containing Compounds in Pharmaceuticals

Among phosphorus containing pharmaceutical compounds, bisphosphonates is a very important class. Therapeutic uses of bisphosphonates include maagement of malignancy-associated hypercalcemia, treatment of postmenopausal osteoporosis and cancer. Bisphosphonates, as a group of active pharmaceutical compounds, generally "give headache" to analytical chemists. The two phosphonic groups per molecule lend a strongly ionic character and increased polarity to these compounds. Additionally, the majority of the members of this family lacks of chromophores, or even has a weak one, excluding convenient sensitive UV or fluorescence detection.This work is devoted to the determination of three bisphosphonate drugs commercially available in the local Egyptian market (alendronate, etidronate and risedronate.The usefulness of different spectrophotometric and chromatographic methods was exploited.The proposed methods are of great value in quality control analysis of the studied compounds owing to their improved simplicity, sensitivity, low-cost, and its independence on expensive instruments, or critical analytical reagents.

Autorentext

Dr. Rania El-Shaheny is a lecturer in Department of Analytical chemistry, Faculty of Pharmacy, Mansoura University, Egypt. She received MSc and PhD in Analytical Chemistry from Fcaulty of Pharmacy, Mansoura University. Her research interests include pharmaceutical analysis, quality control, stability studies of drugs and therapeutic drug monitoring.