Animal Models of Brain Tumors

This book brings together developments in 'in vivo' experimental tumor research of the last two decades that have advanced understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms.

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in in vivo experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results.

Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Brings together recent discoveries and developments in brain tumor cellular and molecular mechanisms Includes detailed protocols that are ready for the lab Features expert tips and key implementation advice to ensure successful results

Inhalt

Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?.- Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints.- The VM Mouse Model of Glioblastoma Multiforme.- Oligodendroglioma Models.- Medulloblastoma Model.- Learning about Retinoblastoma from Mouse Models that Missed.- Ependymoma Models.- Meningioma Models.- Pituitary Models.- Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors.- Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children.- EGFR and TumorSuppressor Function in Brain Cancer Development.- Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts.- Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models.- Assessing Mechanisms of Glioblastoma Invasion.- Positron Emission Tomography (PET)-Based Molecular Imaging.- In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)- Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research.