Anti-cancer activities of some bacterial polysaccharides derivatives

BSL could be a promising anti-initiation agent in vitro through inhibition of CYP 1A mediated carcinogen metabolism and induction of GST activity as well as GSH level. BSL also possesses anti-inflammatory activity through its capacity to enhance macrophage proliferation rate and its ability to inhibit stimulated NO, TNF- and COX-2 levels. Besides preventing tumor promotion, BSL showed inhibitory activity toward DNA fragmentation and cytotoxic property against Hep-G2 tumor cell line as anti-progression properties. In vivo administration of BSL before and after DEN induction showed inhibitory activity toward HDAC and lipid peroxidation which induced by DEN. Also, BSL modulates GST-P expression which upregulated with DEN injection. It resulted in a significant increase in GST activity and GSH level. It downregulates TNF- level and induced apoptosis. Anti-progression properties of BSL represented by its inhibitory activities to DNA fragmentation and VEGF where PDGF level was unaffected. Furthermore, . Garlic showed an induction in GST activity and GSH level and it increases TNF- and decreases VEGF level.

Autorentext

Azza El Amir Professor El Amir A. M., Departamento de Zoologia, Faculdade de Ciências, Universidade do Cairo. Especialista em Imunologia desde 1993. Está tão interessada em assuntos de imunoparasitologia, especialmente tratamento e diagnóstico e protecção de parasitas endémicos novamente endémicos.