Anticlastogens in Mammalian and Human Cells

Anticlastogens are antimutagens, i.e. they protect chromosomes from the damaging action of chemical and physical mutagens. The presented data obtained from in vitro as well as in vivo studies are discussed as aspects of importance in mutagen-exposed humans.

Inhalt
1 Introduction.- 2 Principles of Clastogenic Action and Its Estimation.- 2.1 Molecular Mechanisms of Clastogenic Action.- 2.2 Induction of Chromosome Aberrations.- 2.3 Induction of Sister Chromatid Exchange (SCE).- 2.4 Induction of Micronuclei.- 2.5 Practical Aspects of Clastogenicity and Its Estimation.- 3 Anticlastogens: Data and Problems.- 3.1 Definition and Classification of Anticlastogens.- 3.2 Anticlastogenic Action on in Vitro Systems.- 3.3 Anticlastogenic Action in Vivo.- 3.4 Action of Anticlastogens on Sister Chromatid Exchange (SCE).- 3.5 A Mainly Historical Side-Glance at Anticlastogens and Ionizing Radiation.- 4 Practical Consequences.- 4.1 Practical Consequences in the Field of Anticlastogen Research.- 4.2 Practical Consequences for Humans.- 5 Concluding Remarks.- References.