Antihyperglycemic Activity of Oxazolidine Derivatives

The number compounds have been prepared in order to improve the pharmacological profiles of antihyperglycemic activity. The series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4''-nitrophenyl amino)-1, 3-oxazolidines 6a-e were tested against hyperglycemic activity. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. The results of studies indicate that the compounds 6a, b, c, d, e displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, 1H-NMR, mass spectral and elemental analysis.

Autorentext

Dr. T. Panneerselvam Is working as an Associate Professor in Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu. He earned Young Faculty Award 2014 and he has 08 years of teaching and research experience. His research has focused on the Design, Synthesis, and Analytical/Biological Screening of Novel Heterocyclic Derivatives.