ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL OF GOLD NANOPARTICLES

This study evaluated the chemical profile, antioxidant and anti-inflammatory activity, in an unprecedented way, of AuNPs (AuNPs) synthesized from the NEO of the cross-EO (NEO) of Alpinia zerumbet, Cinnamomum verum and Syzygium aromaticum. The majority constituent of the EO was p-cymene (43.04%) and eugenol (36.25%). The maximum SPR band was centered at 520 nm, indicating the characteristic peak of AuNPs. The lowest IC50 0.69 mg/L for antioxidant activity was obtained for AuNP pH 10. The IC50 that showed the best result for anti-inflammatory activity was that of pH 9 with 7.48x10-9 mg/mL. The best result found for toxicity against Artemia salina was found for AuNPs at pH 7 with LC50 2511.89 mg/L. Finally, in an unprecedented way, antioxidant and anti-inflammatory activity was obtained for AuNPs from a cross EO of Alpinia zerumbet, Cinnamomum verum and Syzygium aromaticum, showing efficiency in the activities tested, also demonstrating the effect of pH on these formulations.

Autorentext
Bachelor's degree in industrial chemistry from the Federal University of Maranhão and Researcher at the essential oils research and application laboratory - LOEPAV/UFMA.