APPLICATION OF SOLID-STATE KINETICS TO DESOLVATION REACTIONS

The book presents an overview of the solid-state
kinetic literature including methodologies used,
mathematical derivations and pharmaceutical
applications.
The book investigates the relationship between
calculation methods and artifactual results observed
in solid-state kinetics. A new approach is proposed
for evaluating solid-state kinetic data, this
approach combines modelistic and model-free methods
in a complimentary manner to achieve consistent
kinetic results.
Experimental data focused on studying the solid-state
stability of several structurally
related solvates of sulfameter
(5 methoxysulfadiazine), this was done by studying
the kinetics of their desolvation reaction both
isothermally and nonisothermally. Calculated kinetic
parameters were compared and related to the crystal
structure of these solvates. A relationship was
established between desolvation kinetic parameters
(e.g., activation energy) and the solvent size. The
solid-state reaction models selected also
corresponded to the single crystal structure of the
sulfameter-solvate system.

Autorentext
Ammar Khawam was born in Damascus. He finished his B.S. in Pharmacy from the Jordan University of Science and Technology where he worked for 3 years in the pharmaceutical industry before joining the University of Iowa to earn a Ph.D. in Pharmaceutical sciences. He is currently a senor scientist at Boehringer Ingelheim pharmaceuticals.

Klappentext
The book presents an overview of the solid-state kinetic literature including methodologies used, mathematical derivations and pharmaceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5-methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.