Automated Sample Preparation

Provides the tools and background for implementation of instrumental sample preparation workflow concepts for GC-MS and LC-MS analyses in the laboratory. The analytical advantages of its implementation and operational aspects during sample handling are discussed.

Autorentext
Hans-Joachim Hübschmann graduated as Certified Food Chemist from the Technical University in Berlin, Germany, working on residue analysis of anabolic agents and pesticides in foods. He started his career in diagnostics, medical analytical instruments and application development working for a number of German companies in chromatography, mass spectrometry and in biotechnology. He joined Thermo Fisher Scientific in Bremen, Germany, and held several international positions covering inorganic and isotope ratio mass spectrometry specializing in food safety, forensic and dioxin analysis. In 2015 he established the independent consulting agency HANS Analytical Solutions for the development of automated sample preparation workflows. In his current capacity he is located in Osaka, Japan, as the Vice President Sales of CTC Analytics for the emerging Asia/Pacific region.

Inhalt

1. Introduction

2. The Analytical Process
   2.1 Laboratory Logistics

3. Workflow Concepts
   3.1 Sample Preperation Workflow Design
   3.2 Instrumental Concepts
   3.3 Sample Processing
   3.4 Tool Change
   3.5 Object Transport
   3.6 Vial Decapping

4. Analytical Aspects
   4.1 Liquid Handling
   4.2 Solid Materials Handling
   4.3 Weighing
   4.4 Extraction
   4.5 Clean-Up Procedures
   4.6 Centrifugation
   4.7 Evaporation
   4.8 Deriatization
   4.9 Temperature Control
   4.10 Mixing

5. Integration into Analysis Techniques
   5.1 GC Volatiles Analysis
   5.2 GC Liquid Injection
   5.3 LC-GC Online Injection
   5.4 LC Injection

6. Solutions for Automated Analysis
   6.1 Dilution
   6.2 Derivatization
   6.3 Taste and Odor Compounds Trace Analysis
   6.4 Sulfur Compounds in Tropical Fruits
   6.5 Ethanol Residues in Halal Food
   6.6 Volatile Organic Compounds in Drinking Water
   6.7 Geosmin in 2-MIB
   6.8 Solvent Elution from Charcoal
   6.9 Semivolatile Organic Compounds
   6.10 Polyaromatic Hydrocarbons in Drinking Water
   6.11 Fatty Acid Methylester
   6.12 MCPD andGlycidol in Vegetable Oil
   6.13 Mineral Oil Hydrocarbons MOSH/MOAH
   6.14 Pesticides Analysis - QuEChERS Extract Clean-Up
   6.15 Glyphosate, AMPA, and Glufosinate by Online SPE-LC-MS
   6.16 Pesticides, PPCPs, and PAHs by Online SPE-Water Analysis
   6.17 Residual Solvents
   6.18 Chemical Warfare Agents in Water and Soil
   6.19 Shale Aldehydes in Beer
   6.20 Phthalates in Polymers

   A. Appendix
   A.1 Robotic System Control
   A.2 System Maintenance
   A.3 Syringe Needle Gage
   A.4 Pressure Units Conversion
   A.5 Solvents
   A.6 Material Resistance