Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis.

This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy.

Autorentext
Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Inhalt

I. Molecular Mechanisms
Chapter 1. Overview of Autophagy
Chapter 2. Molecular Mechanisms Underlying the Degradation of Peroxisomes
Chapter 3. Role of Poly (ADP-Ribose) in Catalyzing Starvation-Induced Autophagy
Chapter 4. Cross-Talk Between Autophagy and Death Receptor Signaling Pathways
Chapter 5. Role of Autophagy in Mammalian Embryogenesis: Response to Developmental Programs
Chapter 6. Autophagy in Adipose Tissue
Chapter 7. Prevention of Adverse Metabolic Consequences of Adipocyte Dysfunction Using MR Antagonists
Chapter 8. A Rapid Method for Detecting Autophagy Activity in Live Cells Using Cellometer Image Cytometry

II. Role in Disease
Chapter 9. CDC37: Implications in Regulation of Kinases and Proteins Linked to Neurodegenerative and Other Diseases
Chapter 10. Autophagy in the Degeneration of Optic Nerve and Spinal Cord Axons
Chapter 11. Membrane Type-1 Matrix Metalloproteinase-Regulated Autophagy: A Role in Brain Cancer Chemoresistance
Chapter 12. Induction of Autophagy and Apoptosis in Melanoma Treated with Palladacycle Complexes
Chapter 13. Autophagy in Atherosclerosis