Beta2-Adrenergic Receptor Gene Haplotypes in COPD

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide, and represents a huge and growing economic and social burden. COPD is a multi-factorial disorder caused by environmental determinants and genetic risk factors. The beta2-adrenergic receptor (2-AR) mediates various physiologic responses of the airways. Alterations in the ADRB2 gene have a significant physiologic role in regulating responses to exogenous 2-agonists. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens.

Autorentext

Mohammad H Hussein have master degree in Chest Diseases, Faculty of Medicine, Cairo University, Egypt. Over past 10 years he has concerned about genotype-phenotype correlation in cardiopulmonary diseases.