BIOANALYTICAL ESTIMATION OF IMIQUIMOD IN RABBIT PLASMA BY RP-HPLC

The present study focuses on the identification and estimation of drugs in the biological matrix using a sophisticated analytical technique also studying their pharmacokinetic parameters like half-lives and rates of elimination and their metabolites in blood. Imiquimod topical treats external warts around the genital and rectal areas called condyloma acuminatum. A direct relationship exists between the drug concentration at the bio-phase (site of action) and the concentration of the drug in plasma. A typical plasma drug concentration-time curve obtained after a single oral dose of a drug and showing various pharmacokinetic and pharmacodynamic parameters.

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Prachet Pinnamaneni est un apprenant enthousiaste qui travaille dur pour rechercher toutes les possibilités de connaissance et répondre aux besoins de la société par le biais d'une recherche solide. Il travaille actuellement comme professeur adjoint au département d'analyse pharmaceutique de l'Institut Chalapathi des sciences pharmaceutiques, à Guntur, dans l'Andhra Pradesh.