Biochemistry of Lipids, Lipoproteins and Membranes

Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences.

As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

Autorentext
Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer's, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements. Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body and how different fats can either lead to, or prevent, chronic disease. He's particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.

Klappentext
Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences.

As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

Inhalt

1. Functional roles of lipids in biological membranes
   Mikhail Bogdanov and William Dowhan
   
   2. Methods of lipid analysis
      Bebiana C. Sousa, Michael J.O. Wakelam and Andrea F. Lopez-Clavijo
   3. Fatty acid and phospholipid biosynthesis in prokaryotes
      Jessica M. Gullett and Charles O. Rock
   4. Lipid metabolism in plants
      Katherine M. Schmid
   5. Fatty acid handling in mammalian cells
      Richard Lehner and Ariel D. Quiroga
   6. Fatty acid desaturation and elongation in mammals
      Lucas M. O'Neill, Makoto Miyazaki, Laura M. Bond, Sarah A. Lewis, Fang Ding, Zhaojin Liu and James M. Ntambi
   7. Phospholipid synthesis in mammalian cells
      Neale Ridgway
   8. Phospholipid catabolism
      Dakai Zhang and Guangwei Du
   9. Sphingolipids
      Anthony H. Futerman
   10. Cholesterol synthesis
       Andrew J. Brown, Hudson W. Coates and Laura J. Sharpe
   11. Structure and function of lipid droplets
       Hongyuan Yang and Jun Liu
   12. Bile acid metabolism
       Jennifer K. Truong and Paul A. Dawson
   13. Lipid modification of proteins
       Marilyn D. Resh
   14. Inter- and intra-membrane lipid transport
       Vesa M. Olkkonen and Elina Ikonen
   15. High-density lipoproteins metabolism and protective roles
       Valentin Blanchard and Gordon A. Francis
   16. Assembly and secretion of triglyceride-rich lipoproteins
       Eric A. Fisher and Roger S. McLeod
   17. Lipoprotein(a)
       Michael B. Boffa and Marlys L. Koschinsky
   18. Lipoprotein receptors
       Kristina Kuhbandner, Joachim Herz and Theresa Pohlkamp
   19. Atherosclerosis
       Murray W. Huff and Katey J. Rayner
   20. Diabetic dyslipidaemia
       Khosrow Adeli, Changting Xiao, Victoria Higgins, Jennifer Taher, Sarah Farr and Gary F. Lewis