Biofilms in Endodontics

Biofilm is a microbially derived community characterized by cells that are irreversibly attached to a substratum or interface or to each other, are embedded in a matrix of extracellular polysaccharides that they have produced and exhibit an altered phenotype with respect to growth rate and gene transcription. In 1890 Miller first observed microorganisms in association with pulp tissue and in 1987 first identification of biofilm structures in infected root canals was carried out by Nair. Since then it is explicit that bacteria are causative agent of endodontic infections. Bacteria can exert their pathogenicity via specific virulence factors such as exotoxins, Lipopolysaccharides, Lipoteichoic acid thereby causing either direct or indirect damage to host cells. Endodontic disease is essentially a biofilm-mediated infection with broader bacterial diversity than previously anticipated.

Autorentext

I am a PG third year resident pursuing my Masters in conservative and endodontics under guidance of Dr. Ashwini Prasad in Mahatma Gandhi Dental College .This book provides an overview of Biofilm associated with root canal,challenges we face while eliminating them and recent advancements focusing on complete eradication of biofilms from root canal.