Biological activities of 1,3,4-oxadiazole Derivatives

1, 3, 4-Oxadiazole are heterocyclic compounds containing one oxygen & two nitrogen atom in a five membered ring. 1,3,4-oxadiazole derivatives have to placed a major role in the pharmaceutical chemistry .The number of so many synthetic compounds with oxadiazole nucleus used for antibacterial ,antifungal , analgesic and anti-inflammatory activities .Derivatives of 1,3,4-oxadiazole with suitable substitution at 2,5 position have been already reported to possible biological activities . 1,3,4-oxadiazole derivatives act as anticonvulsant & diuretics. These observation and our interest in the pharmaceutical chemistry of heterocyclic compounds promoted us,we have synthesized different derivatives of,1,3,4-oxadiazole with different substituent at 2&5-position . These derivatives have been also screened for their anti-inflammatory activity.Mostly five membered aromatic system having three heteroatom s at symmetrical position have been studied because of their physiological properties.It is also well established that various derivatives of 1,3,4-oxadiazole exhibit broad spectrum of pharmacological properties such as antibacterial and anti-fungal activities.

Autorentext

Dr. Arvind K. Singh is working as a Post Graduate Teacher in Department of Education, Govt. of Uttar Pradesh, India since 2011 . Dr. Singh received doctor of Philosophy degree from Banaras Hindu University, Varanasi in 2010. Dr. Singh has published more than one dozen research articles in national and international journals.