Biological Barriers to Protein Delivery

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

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Cellular Barriers: The Paracellular Pathway; M. Cereijido, et al. Ectopeptidases; N.M. Hooper. Epithelial Barriers: Macromolecular Transport Across the Intestinal Epithelium; M. Neutra, J.P. Kraehenbuhl. Oral Cavity; H.P. Merkle, G. Wolany. Vascular Barriers: Vascular Endothelial Barrier Function and its Regulation; A.B. Malik, A. Siflinger-Birnboim. Transcytosis of Macromolecules through the FluidBrain Barriers In Vivo; R.D. Broadwell. Elimination Barriers: Renal Uptake and Disposal of Proteins and Peptides; R. Rabkin, D.C. Dahl. The Immune System as a Barrier to Delivery of Protein Therapeutics; M.W. Konrad. Tissue Barriers: Extravasation and Interstitial Transport in Tumors; R.K. Jain, L.T. Baxter. Diffusion, Bulk Flow, and Volume Transmission of Proteins and Peptides within the Brain; C.E. Johanson. 6 additional articles. Index.