Biological DNA Sensor

Defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. (Immunology)

Autorentext

Advances in Intelligent Vehicles presents recent advances in intelligent vehicle technologies that enhance the safety, reliability, and performance of vehicles and vehicular networks and systems. This book provides readers with up-to-date research results and cutting-edge technologies in the area of intelligent vehicles and transportation systems. Topics covered include virtual and staged testing scenarios, collision avoidance, human factors, and modeling techniques.

The Series in Intelligent Systems publishes titles that cover state-of-the-art knowledge and the latest advances in research and development in intelligent systems. Its scope includes theoretical studies, design methods, and real-world implementations and applications.

Zusammenfassung

"The overall themes are the discovery of double-stranded DNA immunogenicity and the definition of DNA sensing pathways, double-stranded DNA and its part in modulating human diseases, and the DNA sensing pathway and its impact on vaccinology." --ProtoView.com, April 2014

Inhalt

1. Route to discovering the immunogenic properties of DNA from TLR9 to cytosolic DNA sensors
   Choon Kit Tang, Cevayir Coban, Shizuo Akira, Ken J Ishii
   
   2. The PYHIN family of molecules and their functions sensing dsDNA
      Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Katherine A. Fitzgerald
   3. The central role of STING-TBK1 in the DNA sensing pathway
      Glen Barber
   4. Regulation of intracellular dsDNA-induced innate immune responses by autophagy-related proteins
      Running title: Autophagy and dsDNA-induced innate immunity
      Tatsuya Saitoh
   5. Host DNA Induced Inflammation and Autoimmune Diseases
      Surya Pandey, Taro Kawai
   6. Systemic lupus erythematosus and the DNA sensing pathway
      Ann Marshak-Rothstein
   7. Bacterial infections and the DNA sensing pathway
      Jan Naujoks, Bastian Opitz
   8. Viral infections and the DNA sensing pathway: lessons from herpesviruses and beyond
      Søren R. Paludan, Andrew G. Bowie
   9. Cancer Pathogenesis and DNA sensing
      Shen Y.J., Lam A.R., Ho S.S.W., Koo C.X., Le Bert N., Gasser S.
   10. Atherosclerosis and Aging and DNA sensing
       Moshe Arditi
   11. DNA Vaccines: Does it Target the Double Stranded-DNA Sensing Pathway?
       Cevayir Coban, Miyuki Tozuka, Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita, Choon Kit Tang, Ken J. Ishii
   12. Adjuvants targeting the DNA sensing pathways - Alum based adjuvants
       Christophe J. Desmet
   13. Adjuvants Targeting the DNA Sensing Pathways- Cyclic-di-GMP and Other Cyclic-di-Nucleotides
       Rebecca Schmidt, Laurel L. Lenz