Biotechnologies for Gene Therapy

The purpose of this book is to highlight some of latest developments and applications of CRISPR, RNA, and DNA to treat diseases ranging from cancers to cardiovascular and degenerative disorders. It also features innovations of the delivery methods for nucleic acids ranging from nanodevices made from DNA and pseudo amino acids to viral vectors. This is an ideal book for academics, clinicians, and students interested in gene therapy.

Addresses the delivery microRNA and CRISPR for a variety of diseases, including cancer and cardiovascular disease Illustrates the delivery methods and techniques for preclinical applications of miroRNA and CRISPR gene therapy Identifies biotechnologies for gene therapy that have the potential for developing into new clinical therapies

Autorentext

Dr. Yang Yun is an Associate Professor in the Biomedical Engineering Department at the University of Akron. His research interested include biomaterials, cancer therapy, drug and gene delivery, electrospinning, nanotechnology, tissue engineering, and the treatment of infectious diseases. Dr. Kristine Yoder is an Associate Professor in the department of Cancer Biology and Genetics at Ohio State University.

Inhalt

1. Therapeutic potential of microRNAs and their nanoparticle-based delivery in the treatment of liver fibrosis.- 2. MicroRNA as a versatile regulator of Wnt signaling pathway in colorectal cancer.- 3. Small Activating RNA Therapy for Angiogenesis.- 4. Muscular dystrophy therapy using viral vector-based CRISPR/Cas.- 5. CRISPR-Cas based gene therapy to target viral infections.- 6. CRISPR targeting the integrated HTLV-1 virus.- 7. Retroviral vectors for gene therapy of monogenic diseases.- 8. DNA Origami Nanodevices for Therapeutic Delivery Applications. <p