Bisindole derivatives

On the basis of bis(1H-indol-5-yl)methane derivatives 2,2'-diethoxycarbonyl-bis(indol-5-yl)methane and 2,2'-diethoxycarbonyl-3,3'-bisdimethyl- bis(indol-5- yl)methane were obtained 3,3'- bisphenylpiperazinomethyl, 3,3'-biscyanomethyl derivatives, tetracarboxylic acid and its tetraethylester. And on the basis of 2,2'- diethoxycarbonyl-3,3'-diformyl-bis(indol-5-yl)methane bisisonicotinoylhydrazone. The following reactions were studied: piperazinomethylation reaction of 2,2'- diethoxycarbonyl-bis(indol-5-yl)methane, alkylation reactions of phenylpiperazine and KCN with 2,2'- diethoxycarbonyl-3,3'-bisdimethylaminomethyl- bis(indol-5-yl)methane, alkaline hydrolysis and acid alcoholysis reactions of 2,2'-diethoxycarbonyl-3,3'- di(cyanomethyl)- bis(indol-5-yl)methane. The corresponding compounds were obtained. The condensation reactions of 2,2'-diethoxycarbonyl-3,3'- diformyl- bis(indol-5-yl)methane with isonicotinoylhydrazide, aniline and its mono- nitroderivatives. The structure of the obtained compounds was established on the basis of spectral data.

Autorentext

Tamara Doroshenko, born in 1986 in Tbilisi, Georgia, studied chemistry at Tbilisi State University from 2004-2010 and obtained Master Degree (Prof. Samsoniya) for research on bisindole derivatives in 2010. PhD student at Saarland University (Prof U. Kazmaier) since 2011. The topic of research - allylic alkylation of chelated enolates.

Klappentext

On the basis of bis(1H-indol-5-yl)methane derivatives 2,2''-diethoxycarbonyl-bis(indol-5-yl)methane and 2,2''-diethoxycarbonyl-3,3''-bisdimethyl- bis(indol-5- yl)methane were obtained 3,3''- bisphenylpiperazinomethyl, 3,3''-biscyanomethyl derivatives, tetracarboxylic acid and its tetraethylester. And on the basis of 2,2''- diethoxycarbonyl-3,3''-diformyl-bis(indol-5-yl)methane bisisonicotinoylhydrazone. The following reactions were studied: piperazinomethylation reaction of 2,2''- diethoxycarbonyl-bis(indol-5-yl)methane, alkylation reactions of phenylpiperazine and KCN with 2,2''- diethoxycarbonyl-3,3''-bisdimethylaminomethyl- bis(indol-5-yl)methane, alkaline hydrolysis and acid alcoholysis reactions of 2,2''-diethoxycarbonyl-3,3''- di(cyanomethyl)- bis(indol-5-yl)methane. The corresponding compounds were obtained. The condensation reactions of 2,2''-diethoxycarbonyl-3,3''- diformyl- bis(indol-5-yl)methane with isonicotinoylhydrazide, aniline and its mono- nitroderivatives. The structure of the obtained compounds was established on the basis of spectral data.