Bone and Cartilage Engineering

Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.

A complete overview on basic and applied strategies in modern skeletal reconstruction Focussing on preclinical models and clinical applications Provides basic and advanced skills for the clinical application of skeletal engineering Includes supplementary material: sn.pub/extras

Klappentext

Bone and Cartilage Engineering presents the theory and practice of cell-based regeneration of skeletal defects. Much of the focus is on the importance of the cell biological and biomaterial aspects for engineering a clinically relevant device. The basic key techniques for optimal engineering outcomes including cell and organ culture, biomaterial development, and bioreactor use are described in detail and highlighted by multiple figures. Cell-matrix and cell-biomaterial interactions are discussed for evaluating different tissue engineering strategies. Focusing also on preclinical models, clinical applications, ethical, and regulatory issues, this book provides state-of-the art information on cell-based skeletal tissue engineering.

Inhalt
Bone and Cartilage.- Principles of Bone and Cartilage Reconstruction.- Cell Development, Cell Sources.- Harvesting and Cultivation.- Materials.- Cells/Surface Interactions.- Bioreactors and Cell Stimulation.- Scaffold Structure and Fabrication.- Tissue Reconstruction in vivo.- Clinical Handling and Control.- Ethical Considerations in Bone and Cartilage Tissue Engineering.- Future Prospects.