Botulinum Toxin in Urology

The minimally invasive use of botulinum toxins (BoNT) in the lower urinary tract has changed treatment of difficult bladder, urethra and prostate conditions refractory to conventional therapy. This book examines the use of BoNT in the genitourinary tract.

Bladder injection of onabotulinumtoxinA for the treatment of urinary incontinence due to neurogenic detrusor overactivity has recently been approved by regulatory agencies in several EU countries and by the FDA in the United States. This is the first book to focus on the practical application of botulinum toxin (BoNT) in the genitourinary tract. It covers in detail applications of BoNT in the bladder and the prostate and pelvic floor, with reviews of the latest clinical series and techniques in both adults and children. Appendices containing easy-to-read instructions for patients undergoing bladder and prostate BoNT injections are included, in addition to procedural guidelines for nursing staff. The book is written in a concise, clinically relevant style by two leading pioneers in the field, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract.

The first book devoted to use of botulinum toxin (BoNT) in the genitourinary tract, a hot topic following FDA approval of onabotulinumtoxinA for treatment of urinary incontinence due to neurogenic detrusor overactivity Includes reviews of the latest clinical series and techniques of BoNT injection Written and edited by leading pioneers Designed to be of practical assistance to all urologists and urogynecologists wishing to use BoNT

Klappentext
The minimally invasive use of botulinum toxin (BoNT) in the lower urinary tract has revolutionized the treatment of debilitating bladder, urethra, and prostate conditions refractory to conventional therapy. This is the first book focusing on the practical application of BoNT to the genitourinary tract. An introductory section discusses the biology, pharmacology, and safety of BoNT in the lower urinary tract. Applications of BoNT in the bladder and the prostate and pelvic floor are then covered in detail, with reviews of the latest clinical series and techniques of BoNT injection in both adults and children. The book closes by considering non-genitourinary uses of BoNT and addressing issues of health economics as well as providing insights from experts from across the world. This is a practical, hands-on book that also includes appendices containing easy to read instructions for patients undergoing bladder and prostate BoNT injections and specific nursing procedural issues. The book is written in a concise, uniform, and clinically relevant style by two leading pioneers in the field, Drs. Michael Chancellor and Christopher Smith, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract. Botulinum Toxin in Urology will be of interest to all urologists and urogynecologists who are considering the use of BoNT in their practice.

Inhalt
Rationale and Safety for BoNT: Safety and general principles. Biology and mechanism of action.- Bladder: Neurogenic bladder (NDO). Idiopathic overactive bladder (IDO). Interstitial cystitis/painful bladder syndrome. Pediatric use of botulinum toxin.- Prostate and Pelvic Floor: Prostate. Sphincter and pelvic floor disorders.- Role of BoNT in Medicine: Nongenitourinary uses of BoNT. Health economics. Perspectives from around the world. Appendix 1: Patient Instruction bladder. Appendix 2: Patient Instruction prostate. Appendix 3: Nursing issues with botulinum toxin.