Brain Tumors

This volume explores the latest models and techniques used to study brain tumor biology. Chapters in this book are organized into four sections: in vivo models, ex vivo models, treatments in mice, and clinical imaging. Some of the topics covered in this book are in vivo preclinical models of lower-grade gliomas, medulloblastoma, and brain metastases; ex vivo methods for glioblastoma patient-derived cell lines and organotypic brain cultures for metastasis; in vivo treatments of preclinical models that assess neurological function, dynamic immunotherapy, and neurological impacts of brain irradiation; and clinical imaging and modeling, such as biomechanics and vascular perfusion. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and practical, Brain Tumors is a valuable resource that will help readers understand the heterogeneity of the techniques used to study the complexity of brain tumors.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
Mouse Models of Diffuse Lower-Grade Gliomas of the Adult.- In Vivo Medulloblastoma Modeling.- In Vivo Models of Brain Metastases.- Intravital Imaging of Brain Tumors.- Glioblastoma Patient-Derived Cell Lines: Generation of Non-Adherent Cellular Models from Brain Tumors.- Organotypic Brain Cultures for Metastasis Research.- Human Glioblastoma Organoids to Model Brain Tumor Heterogeneity Ex Vivo.- In Vitro Mechanobiology of Glioma: Mimicking the Brain Blood Vessels and White Matter Tracks Invasion Paths.- Assessing Neurological Function in Brain Tumor Mouse Model.- Dynamic Immunotherapy Study in Brain Tumor-Bearing Mice.- Experimental and Preclinical Tools to Explore the Main Neurological Impacts of Brain Irradiation: Current Insights and Perspectives.- Mechano-Biological Features in the Patient-Specific Computational Model of Glioblastoma.- Magnetic Resonance Imaging for Quantification of Brain Vascular Perfusion.- MRI Morphometry in Brain Tumors: Challenges and Opportunities in Expert, Radiomic, and Deep-Learning Based Analyses.