BRCA1/2, PALB2 mutations in breast-ovarian syndrome, our series

Breast cancer in Algeria, and more particularly in the western part of the country, has a particular epidemiological character which contrasts with universal data, due to its incidence in young and even very young patients in a historical context of multiple, multi-organ, transmissible family cancers.Our aim is to report on the overall history of index cases and related cases of breast-ovarian syndrome with BRCA1/BRCA2/PALB2 mutations in 38 young patients at the Sidi Bel Abbés Cancer Centre in Algeria.Our long-term objectives are to categorise the main genetic mutations and to develop a panel of genes specific to the different Algerian ethnic groups.

Autorentext

La Professeure BENCHOUK Jesia Asma dirige le service de chirurgie du cancer du sein et du pelvis au Centre de Lutte Contre le Cancer de Sidi Bel Abbés, Algérie. Elle a également mis en place une consultation d'oncogénétique pour dépister les cancers du sein et de l'ovaire liés à des facteurs familiaux, étant donné leur survenue précoce.