Cadmium-Zinc Interactions At The Level Of Reproductive Function

Reproductive function relies primarily on the synthesis of hormones that ensure the development and proper functioning of reproductive systems. The toxic metal, cadmium (Cd), has been widely described as an endocrine disruptor capable of interfering with certain hormones in their synthesis, metabolism and action. Among the known hormonal targets of this metal are the estrogens. In the present work, we planned to study the interactions between Cd and zinc (Zn) in the signaling of the hormone estradiol, especially since it plays an important role in female reproductive function. For this purpose, we combined two types of experimental approaches, in vivo and in vitro, using the zebrafish animal model, as well as a cell model of the astrocytic line U251-MG. Thus, we studied the effects of Cd and Zn on the development and survival of zebrafish at the embryonic stage, on the one hand, and on the other hand, on transcriptional activation, gene expression of estrogenic receptors, and protein and gene expression levels of brain aromatase.

Autorentext

Lina Chouchene is a research scientist of Tunisian origin, born in Sousse in 1985. After obtaining a Master's degree in genetics and biodiversity, she went on to study in greater depth and obtained a Doctorate in biological sciences and biotechnology. She is also the author of several scientific articles and books.