Calcitonin Gene-Related Peptide (CGRP) Mechanisms

This book provides a thorough review of the key recent research into the role of CGRP in health and disease.

In particular, it enables and enriches understanding of CGRP in migraine pathophysiology.

Provides a full update of the latest therapeutic perspectives and clinical advancements with potential therapeutic agents that block the actions of CGRP.

Inhalt

1. CGRP Discovery and Timeline.- 2. CGRP Receptor Biology: Is There More Than One Receptor?.- 3. The Structure of the CGRP and Related Receptors.- 4. CGRP Receptor Signalling Pathways.- 5. Pathways of CGRP Release from Primary Sensory Neurons.- 6. CGRP in Animal Models of Migraine.- 7. CGRP in Human Models of Migraine.- 8. Role of CGRP in Migraine.- 9. Understanding CGRP and Cardiovascular Risk.- 10. CGRP and Painful Pathologies other than Headache.- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.