Calcium, Cadherins, and Cell Adhesion: A Three-Way Dance

In vitro experiments have revealed that CDH17 forms homophilic trans- and cis- complexes in a calcium-dependent manner44,72,8789. A CDH17 inhibitory peptide, designed based on expected structural similarities to classical cadherins, interfered with homophilic trans adhesion in CACO2 cells forming epithelial layers and resulted in interstitial cleft widening72. Experiments also revealed that CDH17 is capable of forming heterophilic trans interactions with the classical cadherin CDH1, which is expressed in the same cell types as CDH1744. However, a structural basis for how CDH16 and CDH17 interact in cis and trans to mediate homophilic and heterophilic adhesion is not known.

Calcium, Cadherins, and Cell Adhesion" unveils the fascinating cellular ballet, revealing how calcium orchestrates the cadherin proteins to sculpt tissues and organs. This captivating read explores the science behind cell adhesion, crucial for development, wound healing, and even diseases.

Autorentext
Professor Dr. Lemony is a visionary energy expert at the forefront of Europe's green transition. Their distinguished career has been dedicated to developing innovative solutions for integrating renewable energy sources into a reliable and sustainable energy grid. Professor Dr. Lemony's particular focus lies on the critical role of energy storage and hydrogen infrastructure in Europe's green shift. "Europe's Green Shift: Storing Renewables and Investing in Hydrogen Infrastructure" represents Professor Dr. Lemony's culmination of years spent researching, analyzing, and advocating for a comprehensive approach to Europe's clean energy future. Professor Dr. Lemony meticulously analyzes the challenges of integrating intermittent renewable energy sources like solar and wind into the existing grid. They explore various storage technologies, from batteries to pumped hydro, highlighting their strengths and limitations in addressing the intermittency issue. Professor Dr. Lemony's passion extends beyond technical solutions. They are a strong proponent of hydrogen as a key element in Europe's green energy strategy. Professor Dr. Lemony delves into the potential of hydrogen as a clean and versatile energy carrier, emphasizing the need for robust hydrogen infrastructure development to unlock its full potential. Professor Dr. Lemony actively collaborates with policymakers, energy companies, and research institutions to translate their vision into practical action. Their writing is known for its clarity, authority, and ability to bridge the gap between complex energy concepts and the real-world challenges facing Europe's green transition. In "Europe's Green Shift," Professor Dr. Lemony embarks on a compelling exploration of the path towards a sustainable energy future. They delve into the critical role of storage and hydrogen infrastructure, showcase successful case studies from around the world, and explore the economic and environmental benefits of a well-integrated renewable energy system. Professor Dr. Lemony's insightful analysis equips readers with the knowledge and tools to become active participants in shaping a clean and secure energy future for Europe.