Campylobacter pylori

Campy/o/meler pylori was described for the first time in 1983. Up to now more than 100 papers have been published dealing with its microbiological properties and its clinical implications. The lime has come to survey the field, to evaluate the hith erto accumulated information, and 10 discuss the questions thai should be answered in the ruture. It was for these purposes that the First International Symposium on Campy/abaeter pylori was held. bringing together specialists from a variety of discipl ines, including basic scientists as well as clinicians. This book is based on papers given at the symposium. We are very grateful 10 Rohm-Pharma for undertaking to sponsor this meeting, and to Mrs. C. 1. Klein and her starr for the impeccable organisation which permillcd us to work in such a pleasant environment, In the interest of rapidity of publication, we have reduced the amount of editing to a minimum and have not, in any sense, "re fereed" the discussions, which were written by the contributors at the time of the question-and-answer session. They were also veiled by their authors at the proof stage, and we have done our best to retain their original spontaneous flavour. We hope, in this way. 10 have produced a satisfactory record of the events and an up-Io-dale overview of research on Campylobacrer pylori.

Klappentext

This is the first book to deal exclusively with the newly described bacterium ICampylobacter pylori/I. It reflects the knowledge accumulated until now in the field and covers: the microbiology and biochemistry of ICampylobacter pylori/I; the pathophysiology of gastritis and peptic ulcer disease; the epidemiology of ICampylobacter pylori/I infection; the diagnosis of ICampylobacter pylori/I infection; and the treatment of chronic gastritis and peptic ulcers with bismuth salts. Readers are therefore offered an up-to-date survey of the latest scientific results on this new topic.

Inhalt
Section 1 Microbiology and Biochemistry ofCampylobacter pylori.- Morphological and Biochemical Characterization of Campylobacter pylori.- Discussion.- Protein Antigens of Campylobacter pylori: The Problem of Species Specificity.- Discussion.- Differences Between in Vitro and in Vivo Sensitivity of Campylobacter pylori to Antibacterials.- Discussion.- In Search of Animal Models for Campylobacter pylori Induced Disease.- Discussion.- An Animal Model of Gastritis Induced by Campylobacter pylori.- Discussion.- Section 2 Pathophysiology of Gastritis and Peptic Ulcer Disease.- Current Theories on Pathogenesis of Peptic Ulcer Disease.- Discussion.- The Mucus Bicarbonate Barrier and Its Role in Gastroduodenal Mucosal Protection.- Discussion.- Semiquantitative Histopathology of Active Chronic Gastritis in Campylobacter pylori Infection and Its Relationship to Peptic Ulcer Disease and Gastric Carcinoma.- Discussion.- Section 3 Epidemiology ofCampylobacter pyloriInfection.- Incidence of Campylobacter pylori in Patients with Gastritis and Peptic Ulcer Disease in Various Countries.- Discussion.- Molecular Epidemiology and Natural History of Campylobacter pylori Colonization.- Discussion.- Campylobacter pylori in Children.- Discussion.- Section 4 Diagnosis ofCampylobacter pyloriInfection.- Monoclonal Antibodies Against Campylobacter pylori.- Production and Characterization of Monoclonal Antibodies Against Campylobacter pylori.- Discussion.- Rapid Identification of Campylobacter pylori in Gastric Biopsies.- Discussion.- Comparison Between Cultural and Histological Techniques in Diagnosis of Campylobacter pylori Colonization.- Discussion.- Experience with 14C-Urea Breath Test in Detecting Campylobacter pylori.- Discussion.- Systemic Immune Responses to Campylobacter pylori Colonization.- Local Immune Responses to Campylobacter pylori Colonization.- Discussion.- Section 5 Treatment of Chronic Gastritis and Peptic Ulcer with Bismuth Salts.- Therapeutic Strategies in Medical Management of Peptic Ulcer Disease.- Discussion.- Gastroprotective and Ulcer Healing Properties of Bismuth Salts.- Discussion.- Treatment of Peptic Ulcer Disease with Bismuth Preparations.- Discussion.- Treatment of Campylobacter Gastritis with Bismuth Salts.- Discussion.- Attempts to Eradicate Campylobacter pylori Dutch Experiences.- Discussion.- Attempts to Eradicate Campylobacter pylori Irish Experiences.- Discussion.- Attempts to Eradicate Campylobacter pylori German Experiences.- Discussion.- Section 6 State of the Art Lecture.- Campylobacter pylori: Addressing the Controversies.- Discussion.