Carbohydrate-Based Therapeutics

The book covers current progress and opens new frontiers in carbohydrate-based therapeutic applications. It presents a detailed background of the diseases coupled with the subsequent carbohydrate-based therapies. This aspect renders this book unique and will serve as a quick reference practical book of carbohydrate applications. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure-activity relationship and impact on health and diseases.

Autorentext
Roberto Adamo joined Novartis Vaccines in 2007 where he was later appointed Head of the Carbohydrate Chemistry Laboratory, and Leader of the Conjugation & Synthesis Platform. After the GSK acquisition of the company he became Preclinical Representative Leader of the Conjugation Platform. He is currently Technology and Project Leader at GSK, Italy. His research focuses on the synthesis of glycans, glycoconjugates and glyconanoparticles to be used for carbohydrate-based therapeutics. He has over 70 publications in the field including a book. He is the Associate editor of the Glycoconjugate Journal.

Luigi Lay is full professor at the Department of Chemistry of the University of Milan. His research interests are focused on carbohydrate chemistry and the use of synthetic glycans to investigate their biological properties. He is author of 86 publications in the field and some book chapters.

Klappentext

Comprehensive resource summarizing opportunities and latest progress in design methodologies for carbohydrate-based therapeutics through a disease-oriented approach Carbohydrate-Based Therapeutics covers current progress and explores new frontiers in carbohydrate-based therapeutic applications, utilizing a unique approach by providing a detailed background of diseases coupled with subsequent carbohydrate-based therapies. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and a broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure- activity relationship, and impact on health and diseases. The text also discusses newer topics like nanoparticles, material science, and tissue generation. Carbohydrate-Based Therapeutics includes information on:

• Antimicrobial carbohydrate-based therapies, covering antibacterial and antiviral vaccines, antifungal therapies, anti-influenza therapeutics, and antiadhesive carbohydrates and glycomimetics
• Anti-cancer carbohydrate-based therapies, covering cancer vaccines and immunotherapy, and carbohydrate tools in cancer biology
• Carbohydrate-based therapies in metabolic, neuronal, and immune disorders, covering carbohydrate-based therapeutics for lysosomal disorders and neurodegenerative diseases

• New frontiers in carbohydrate-based therapies, covering carbohydrates for tissue engineering, antiangiogenic and regenerative medicine Providing comprehensive coverage of foundational knowledge on the subject in a unique and highly accessible format while also exploring the state of the art in the field's applications, Carbohydrate-Based Therapeutics is an essential resource for medicinal, pharmaceutical, and organic chemists, chemists in industry, biochemists, and biotechnologists.

  Inhalt
  PART I
  ANTIMICROBIAL CARBOHYDRATE BASED THERAPIES
  Antibacterial Vaccines
  Antiviral Vaccines
  Antifungal Therapies
  Anti Influenza Therapeutics
  Antiadhesive Carbohydrates and Glycomimetics

  PART II
  ANTI CANCER CARBOHYDRATE-BASED THERAPIES

  Cancer Vaccines and Immunotherapy
  Carbohydrate Tools in Cancer Biology
  Carbohydrates and Glycoconjugates in Autophagy
  Lectin Ligands to Target Cancer

  PART III
  CARBOHYDRATE-BASED THERAPIES IN METABOLIC, NEURONAL AND IMMUNE DISORDERS
  Carbohydrate-Based Therapeutics for Lysosomal Disorders
  Carbohydrate-Based Therapeutics for Neurodegenerative Diseases
  Carbohydrate-Based Antithrombotics
  Glycans and Blood Types
  Carbohydrate-Based Therapeutics for Autoimmune Diseases
  N-Glycosylation of Antibodies and Immunity
  Type 1 Diabetes

  PART IV
  NEW FRONTIERS IN CARBOHYDRATE-BASED THERAPIES
  Carbohydrates for Tissue Engineering
  Antiangiogenic and Regenerative Medicine
  Carbohydrate-Based Therapeutics for Bowel Diseases