CD4+CD25+T cells in HCV patients & Prevalence of Bacterial infection

CD4+CD25+Treg lymphocytes are a subset of circulating CD4+T cells with suppressive properties. CD4+CD25+ Treg cells suppress HCV-specific T cell responses. They may play a role in viral persistence. Our study was designed to assess the frequency of Treg cells as well as occurrence of bacterial infection in different clinical presentation of HCV infection in a chosen Egyptian population. Data obtained showed high significant frequency of CD4+CD25+Treg cells in all HCV patients in comparable to healthy individuals. Conversely, within different clinical degrees of HCV infection no significant differences were detected. Higher Frequency of CD4+CD25+ Treg cells detected in HCV patients than in normal individuals may help to be used as a marker for early detection of viral disease and open new area to find a way to disease recovery/protection. The prevalence of bacterial infection among HCV patients was significant high as detected in both blood and urine samples specially among those with late disease episode. Staphylococcus aureus and beta-hemolytic Streptococcus viridanse were the common infected organisms in blood samples of HCV patients. In urine samples, Escherichia coli was detected.

Autorentext

Professor of Microbiology at Suez Canal University, got her MSc dgree in 1986, PhD dgree in 1991 through cooperation between Harvard Univ. and SCU, Associate Prof. in 1997&Prof. in 2003, Head of Botany Dept at SCU in 2009 till May 2012. She is interested in many fields: Medical Micro., Applied Biotechnology, N2 fixation, Actinomyetes& Agro-forestry