Cell Signaling Pathways and Their Therapeutic Implication in Cancers

This book discusses different signaling pathways involved in tumor development and progression. It discusses the pathways that allow tumor cells to proliferate, survive, and invade other tissues. Further, the book reviews the signal transduction regulating phagocytosis, production of cytokines, cell division, and differentiation. It elucidates the dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer and enumerates the signaling network encompassing the extracellular matrix, blood vessels, and the immune system. Additionally, the book provides mechanistic insights into inhibitors of the receptor tyrosine kinases, BRAF, EGFR, and ALK that improve clinical response and increase the survival of patients with cancer. The book covers the signal transduction pathways that regulate cell cycle progression and genomic stability, providing a mechanistic understanding of the major checkpoint pathways, and reviewing their diagnostic and therapeutic potential. This volume is essential reading for researchers to understand the therapeutic potential of important signaling molecules against cancer.

Presents signalling pathways that play central roles in multiple processes associated with cancer Covers molecular targeting drugs signalling pathways in cancer Discusses signaling pathways that regulate cell cycle progression and genomic stability

Autorentext
Dr. Muneeb U Rehman (PhD) is a faculty member at the College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product pharmacology) from Jamia Hamdard, New Delhi, India. Dr Rehman has more than ten years of research and teaching experience in the fields of toxicology, cancer biology and signalling, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international grants, fellowships and awards. He has published more than various research papers in peer-reviewed, international journals and has a few edited books and book chapters. Dr Rehman is on the editorial boards and is a reviewer of several high-impact, international journals. He is also a life member of various international societies and organisations. Currently, Dr Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.

Dr. Mosin Saleem Khan (PhD) is assistant professor of biochemistry, Government Medical College Baramulla and Associated Hospitals, J&K, India. Previously he worked as a Lecturer/Assistant Professor at Government Medical College Srinagar and Associated Hospitals, J&K, India. He has obtained his doctorate in the Discipline of Medical Biochemistry from the Faculty of Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), J&K, India. Dr Khan has more than 12 years of research and teaching experience in the field of biochemistry, cancer biology, and molecular biology. He has more than fifty research publications in peer-reviewed, reputed international journals to his credit. He has authored a book and a few book chapters on biochemistry and molecular biology. He is a life member of various prestigious organizations like Association of Clinical Biochemists of India (ACBI), Indian Immunology Society (IIS), Society of Biological Chemists of India (SBCI) and Indian Academy of Biomedical Sciences (IABS) and Society of Cancer Research (SCR). Dr Khan is the recipient of the University Gold Medal for M.Sc. Biochemistry by University of Kashmir, J&K, India. Dr Khan has received many scientific awards at the state and national levels. Currently, Dr Khan is working on different molecular aspects of cancers and Diabetes Mellitus and screening newborns and pregnant ladies for various genetic disorders.

Inhalt

Chapter 1. An Introduction to Cell Signalling pathways and their Dysregulation in cancer.- Chapter 2. Involvement of Mitogen activated protein (MAP) Kinase pathway in the etiopathogenesis of cancer and its role in cancer therapeutics.- Chapter 3. Association of PI3K/AKT/mTOR pathway with cancer and its therapeutic implications.- Chapter 4. Role and therapeutic implication of Hedgehog signalling pathway in cancer.- Chapter 5. Hippo LATS pathway in cancer and its role as a potential target for anti-cancer drugs.- Chapter 6. Role and therapeutic implication of Notch signalling pathway in cancer.- Chapter 7. Role and therapeutic implication of Wnt signalling pathway in cancer.- Chapter 8. Involvement and therapeutic implication of JAK-STAT pathway in cancer.- Chapter 9. Role of cAMPPKACREB signalling pathway in cancer.- Chapter 10. Role and therapeutic implications of vitamin D signalling pathway in cancer.- Chapter 11. TGF- signalling pathway in cancer and its therapeutic role.- Chapter 12. Role of signaling pathways regulating cell cycle progression in cancer.- Chapter 13. Role of signaling pathways regulating genomic stability in cancer.