Cell Volume Regulation

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics.

Autorentext
Irena Levitan, PhD, is a Professor of Medicine and Bioengineering at the University of Illinois at Chicago. She received her PhD in Biophysics and Neurobiology at the Hebrew University of Jerusalem in 1994 and completed postdoctoral training at the Medical College of Pennsylvania and Institute for Medicine and Engineering at the University of Pennsylvania. Her research focuses on the biophysical properties of endothelial membranes and sub-membrane cytoskeleton. Specifically, the studies of her group, which combine computational and experimental biophysical approaches, provided the first comprehensive structural insights into cholesterol regulation of K+ channels. In 2012, she was named a Guyton Distinguished Lecturer for her quantitative and biophysical work on cholesterol modulation of ion channels and how this can affect integrated organ function”. She and her group also discovered a paradoxical relationship between fluidity/deformability of the membrane and cell stiffness. In 2018, she was elected a Fellow of AIMBE for outstanding contributions to our understanding of lipid-ion channel interactions, cellular biomechanics and vascular dysfunction under dyslipidemia”. Dr. Eric Delpire teaches at the Vanderbilt University, Nashville, USADr. Hector Rasgado-Flores teaches at Rosalind Franklin University, Chicago, USA

Inhalt
Section 1. General Principles of Cell Volume Regulation
1. Water Homeostasis and Cell Volume Maintenance and Regulation
Eric Delpire and Kenneth B. Gagnon
2. Search for Upstream Cell Volume Sensors: The Role of Plasma Membrane and Cytoplasmic Hydrogel
Sergei N. Orlov, Aleksandra Shiyan, Francis Boudreault, Olga Ponomarchuk, and Ryszard Grygorczyk
3. Cytoskeletal Contribution to Cell Stiffness Due to Osmotic Swelling; Extending the Donnan Equilibrium
Pei-Chuan Chao, Mettupalayam Sivaselvan, and Frederick Sachs
4. Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus
Manuela A.A. Ayee and Irena Levitan
5. Molecular Identities and ATP Release Activities of Two Types of Volume-Regulatory Anion Channels, VSOR and Maxi-Cl
Yasunobu Okada, Toshiaki Okada, Md. Rafiqul Islam, and Ravshan Z. Sabirov
6. Molecular Biology and Physiology of LRRC8 Volume-Regulated Anion Channel (VRAC)
James Osei-Owusu, Junhua Yang, Maria del Carmen Vitery, and Zhaozhu Qiu

Section 2. Regulation of Intracellular Chloride and Water Homeostasis
7. Role of WNK Kinases in the Modulation of Cell Volume
Paola de los Heros, Diana Pacheco-Alvarez, and Gerardo Gamba
8. Intracellular Macromolecules in Cell Volume Control and Methods of Their Quantification
Michael A. Model M.A. and Jonathan C. Petruccelli

Section 3. Cell Volume Regulation in the Airways
9. Slippery When Wet: Airway Surface Liquid Homeostasis and Mucus Hydration
Megan J. Webster and Robert Tarran
10. Physiology of the Gut: Experimental Models for Investigating Intestinal Fluid and Electrolyte Transport
Isha Dey and Neil A. Bradbury

Section 4. Cell Volume Regulation in the Brain
11. Cell Volume Control in Healthy Brain and Neuropathologies
Corinne S. Wilson and Alexander A. Mongin
12. Cytotoxic Swelling of Sick Excitable Cells - Impaired Ion Omeostasis and Membrane Tension Homeostasis in Muscle and Neuron
Catherine E. Morris