Characterization of Hyperpolarized Xe-129 NMR Spectra

This book describes the modeling and experimental
effort in trying to use hyperpolarized Xe-129 (H-Xe)
dissolved in Perfluorooctyl Bromide (PFOB) emulsions
as an Nuclear Magnetic Resonance (NMR) contrast agent
for cancer detection. H-Xe dissolved in PFOB
emulsions stabilized with egg-yolk phospholipid (EYP)
has been suggested as a possible in vivo NMR contrast
agent. A two-compartment radial diffusive exchange
model based on the generalized Bloch equations was
developed. The model was used to investigate the NMR
spectra of H-Xe dissolved in PFOB emulsions. The
permeability of the EYP membrane was estimated by
fitting the linewidths of the experimental NMR
spectra with the modeled spectra linewidths. The
experiments also showed that the linewidths of the
NMR spectra of H-Xe in PFOB emulsions depend on the
PFOB concentration because of the H-Xe diffusive
exchange. Bulk water flow measurements were
demonstrated by dynamic acquisition of H-Xe NMR
spectra while the bolus formed of H-Xe gas in PFOB
emulsions diluted during the passage through a coil.

Autorentext

The author has received a Ph.D. in Physics with specialization inMedical Physics from Carleton University in Ottawa, Canada.Currently, he is a Postdoctoral Fellow in the field of X-rayFluorescence applications in medicine at Mount Allison Universityin Sackville, Canada.

Klappentext

This book describes the modeling and experimentaleffort in trying to use hyperpolarized Xe-129 (H-Xe)dissolved in Perfluorooctyl Bromide (PFOB) emulsionsas an Nuclear Magnetic Resonance (NMR) contrast agentfor cancer detection. H-Xe dissolved in PFOBemulsions stabilized with egg-yolk phospholipid (EYP)has been suggested as a possible in vivo NMR contrastagent. A two-compartment radial diffusive exchangemodel based on the generalized Bloch equations wasdeveloped. The model was used to investigate the NMRspectra of H-Xe dissolved in PFOB emulsions. Thepermeability of the EYP membrane was estimated byfitting the linewidths of the experimental NMRspectra with the modeled spectra linewidths. Theexperiments also showed that the linewidths of theNMR spectra of H-Xe in PFOB emulsions depend on thePFOB concentration because of the H-Xe diffusiveexchange. Bulk water flow measurements weredemonstrated by dynamic acquisition of H-Xe NMRspectra while the bolus formed of H-Xe gas in PFOBemulsions diluted during the passage through a coil.