Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

A recently discovered biological entity attracting growing interest from academics worldwide Plays key roles in normal physiological processes whilst aberrant biosynthesis can lead, or contribute to, disease states Growing impact within the pharmaceutical interest in drugs which manipulate its synthesis or activity Includes supplementary material: sn.pub/extras

Inhalt

Part I Biochemistry, molecular biology and chemistry.- 1 H 2 Ssynthesizing enzymes: biochemistry and molecular aspects.- Part II Molecular mechanisms of action.- 2 Sulfhydration and H 2 S.- 3 Persulfide formation and H 2 S.- Part III Cardiovascular system. - 4 H 2 S and blood vessels - an overview.- 5 Hydrogen sulfide and urogenital tract.- 6 H 2 S - cardiac function and cardiac disease.- 7 H 2 S and platelets a possible role in thrombosis?.- Part IV Inflammation and inflammatory disease.- 8 H 2 S and inflammation - an overview.- 9 H 2 S and neuroinflammation.- Part V H 2 S and the nervous system.- 10 Brain, learning and memory: role in neurodegenerative diseases.- 11 H 2 S and pain inflammatory and neuropathic.- Part VI H 2 S, angiogenesis and cancer.- 12 H 2 S and colon cancer.- 13 The role of H 2 S in cancer and tumor development.- Part VII H 2 S and ageing.- 14 H 2 S a new approach to lifespan enhancement and healthy aging?.- Part VIII H 2 S, measurement and possible therapeutics?.- 15 Measurement of H 2 S probes comes of age?.- 16 S-propargylcysteine a novel H 2 S donor with therapeutic potential.- 17 Mitochondria-targetted sulfide donors.- 18 Medicinal chemistry - insights into the development of novel H 2 S donors.