Cholesterol and Beyond

This is a remarkable, concise history of research on diet and heart disease, which traces the rise and fall of coronary heart disease as the major cause of death in the first world, followed by the rise of this cause of death in the developing world.

Only once in a great while does a book come along that really does the job in addressing a major medical issue. When this happens, all can be joyful Readers will find ALL their favorite dietary puzzlements dealt with With consummate scholarship, clarity and brevity, Truswell sifts out the chaff and identifies the critical questions, the responsible investigators, and the key studies. So says Emeritus Professor Henry Blackburn from the University of Minnesota in the foreword to this remarkable concise book on the history of research on diet and heart disease. This was a theme of scientific, medical and public interest in the 20th Century, a century marked by the rise and fall of coronary heart disease as the major cause of death in the first world, followed by the rise of this cause of death in the developing world. There is obviously much to learn, and this book is an excellent starting point, tracing dietary factors and their role in heart disease one by one: fats, sugar, salt, alcohol, coffee, trans-fats, etc. Without an understanding of the role of diet and the changes that have been seen in the North American and NW European diet, the story of the decline in the heart disease death rate may have been very different.

It describes all the evidence-based research on diet and coronary heart disease from 1900-2000 It is both a part of medical history and a narrative review The author, a physician, has had extensive involvement with research on different dietary components and plasma cholesterol The book is easy to read and unbiased. It is not pushing any particular diet or theory

Inhalt
Emergence of Coronary Heart Disease as a Diagnosis.- Experimental Pathology in St. Petersburg.- Is Plasma Cholesterol Raised with Human Atherosclerosis?.- Diet Can Have Worthwhile Effects on Human Plasma Cholesterol.- A New Type of Observational Epidemiology.- Serum Triglycerides? Another Risk Factor.- Fredrickson's Classification of the Hyperlipoproteinaemias.- The Seven Countries Study (7CS).- Sucrose An Alternative Dietary Hypothesis.- HDL-Cholesterol Is Protective.- Critics and Sceptics.- Thrombosis on and in Atheroma.- Dietary Cholesterol May Affect Plasma Cholesterol.- First Controlled Trials.- Dietary Fibre.- Obesity.- Thrombosis Treated Early.- Fish Oil.- Alcohol.- Coffee.- Trans-Fatty Acids.- Antioxidants.- More Controlled Dietary Trials.- Trials of Better Drugs.- Linoleic Acid is Protective.- Plant Sterols Fade and Return.- Soy Proteins Versus Casein.- High Homocysteine Associated with Cardiovascular Diseases.- And Salt Should Be Included.- How It Adds Up.- The Big Picture.- End Notes.