Clinical Cases in Primary Immunodeficiency Diseases

Focused on features of patients with PIDs and on further investigation and management, this book uses 90 real-life cases of immunideficiency, along with some 300 related questions. Includes clinical diagnosis, lab findings, molecular mechanisms and therapy.

Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.

Designed as a practical, awareness-raising guide for the clinician Provides key information relevant to the diagnosis and management of each primary immunodeficiency (PID) Comprises a series of case-oriented problems drawn from typical patient scenarios Enables prompt recognition of PIDs, thereby helping to avoid delayed diagnosis and its consequences Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras

Inhalt
Recurrent infections.- Combined T- and B-cell immunodeficiencies.- Primary Antibody Deficiencies.- Disorders of Phagocytic Cells.- Immune dysregulation diseases.- Defects in Innate immunity: Receptors and Signaling Components.- Autoinflammatory disorders.- Complement deficiencies.- Other well-defined immunodeficiency syndromes.