Clinical Epidemiology

Clinical Epidemiology is an ideal reference for medical practitioners, basic scientists and allied health professionals who desire to improve clinical outcomes. It focuses on the determination of diagnosis, prognosis and management of human disease.

Clinical epidemiology provides the scientific basis for the practice of medicine due to its focus on the diagnosis, prognosis and management of human disease using appropriate research design, measurement and evaluation. In Clinical Epidemiology: Practice and Methods, leading experts contribute selections intended to educate researchers on how best to undertake clinical research. Divided into two categories, the volume first covers issues of design, measurement and analysis associated with various research designs, then continues with methods to better inform medical decision-making, including aggregation of multiple studies using meta-analysis, health economics, clinical practice guidelines and health technology assessment. As a part of the highly successful Methods in Molecular Biology™ series, this comprehensive text collects the kind of detailed, up-to-date information and implementation advice that is crucial for getting optimal results.

Essential and advantageous, Clinical Epidemiology: Practice and Methods is an ideal reference for medical practitioners, basic scientists and allied health professionals who desire to improve clinical outcomes.

Presents the basic science of practicing physicians and allied health professionals Focuses on determination of diagnosis, prognosis, and management of human disease Outlines the concepts and methods of patient-related research, with an emphasis on research design, measurement, and evaluation Provides a primer on assessing multiple studies to better inform clinical decisionmaking Written by practicing physicians who are active in clinical research

Inhalt
On Framing the Research Question and Choosing the Appropriate Research Design.- Longitudinal Studies and Determination of Risk.- Modeling Longitudinal Data, I: Principles of Multivariate Analysis.- Modeling Longitudinal Data, II: Standard Regression Models and Extensions.- The Design of Randomized Controlled Trials.- Analysis of Randomized Controlled Clinical Trials.- Evaluation of Diagnostic Tests.- Biomarkers and Surrogates in Clinical Studies.- Measurement and Analysis of Patient-Reported Outcomes.- Bias in Clinical Studies of Genetic Diseases.- Genetic Epidemiology of Complex Phenotypes.- Qualitative Research in Clinical Epidemiology.- Primer on Systematic Review and Meta-Analysis.- The Role of Health Economics within Clinical Research.- Development and Limitations of Clinical Practice Guidelines.- Basics of Health Technology Assessment.- Research Ethics for Clinical Researchers.- Budgeting, Funding and Managing Clinical Research Projects.