Coenzyme B12 Enzymes Part A: Volume 668

Informationen zum Autor I am currently Professor of Chemistry and Biological Chemistry at the University of Michigan in Ann Arbor. My research interests center on enzyme mechanisms and protein structure and design. We are currently working on a variety of research projects. In particular, we have a long-standing interest in enzymes that use free radicals to catalyze a variety of unusual chemical transformations. More recently, we have become interested in enzymes involved in hydrocarbon biosynthesis, many of which have novel mechanisms and are of practical interest for the biosynthesis of next-generation biofuels. We are also interested in understanding in molecular detail how enzymes interact with abiological surfaces as this is key to many industrial and biomedical applications where enzymes are immobilized on solid supports. More information about my research can be found here:http://www.lsa.umich.edu/chem/people/faculty/ci.marsheneilg_ci.detail

Autorentext
I am currently Professor of Chemistry and Biological Chemistry at the University of Michigan in Ann Arbor. My research interests center on enzyme mechanisms and protein structure and design. We are currently working on a variety of research projects. In particular, we have a long-standing interest in enzymes that use free radicals to catalyze a variety of unusual chemical transformations. More recently, we have become interested in enzymes involved in hydrocarbon biosynthesis, many of which have novel mechanisms and are of practical interest for the biosynthesis of next-generation biofuels. We are also interested in understanding in molecular detail how enzymes interact with abiological surfaces as this is key to many industrial and biomedical applications where enzymes are immobilized on solid supports. More information about my research can be found here:http://www.lsa.umich.edu/chem/people/faculty/ci.marsheneilg_ci.detail

Inhalt

1. B12 Biosynthesis and B12 Chaperones
   Martin Warren University of Kent, U.K.
   2. Biosynthesis of corrinoids
   Amrita Hazra IISER Pune, India
   3. Guardian of cobamide diversity: probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactors
   Michiko Taga University of California, Berkeley
   4. Purification and Detection of Vitamin B12 Analogs
   Jorge Escalante-Semerena University of Georgia
   5. A method for the efficient adenosylation of corrinoids
   Jorge Escalante-Semerena University of Georgia
   6. A method for the production, purification and liposome reconstitution of cobamide synthase
   Jorge Escalante-Semerena University of Georgia
   7. A method for the Isolation of -ribazole from Vitamin B12, and its Enzymatic Conversion to -ribazole 5'-phosphate
   Ruma Banerjee University of Michigan
   8. The human B12 trafficking chaperones: CblC, CblD and ATR
   Bernhard Kräutler University of Innsbruck, Austria
   9. Synthesis and applications of "antivitamin" B12 derivatives B12-dependent enzyme reactions
   Tetsuo Toraya Okayama University, Japan
   10. Coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyase
   Tetsuo Toraya Okayama University, Japan
   11. Reactivating chaperones for coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyase
   Wolfgang Buckel Marburg University
   12. Glutamate mutase and 2-methyleneglutarate mutase
   Ruma Banerjee University of Michigan
   13. Human B12 dependent enzymes: Methionine synthase and methylmalonyl-CoA mutase
   David Leys Manchester University
   14. Heterologous production and biophysical characterisation of catabolic Nitratireductor pacificus pht-3B reductive dehalogenase
   Nigel Scrutton Manchester University
   15. An unusual light-sensing function for coenzyme B12 in bacterial transcription regulator CarH