Comparative Genomics of Membrane Proteins

In the last five years, a number of genomes from tropical parasites were sequenced. The aim of this project was to perform comparative genomics between different parasites and free-living eukaryotes, with particular emphasis on predicted membrane proteins. From an evolutionary point of view, this provided insights to how different parasites adapted to living within a host. From a pharmacological point of view, the project supported the identification of candidate virulence factors, antigens, and drug targets in parasites. The first part focuses on GPI-anchored proteins, the second one on repeat-containing membrane proteins, and the third part on transporter families.

Autorentext

Niklaus Fankhauser, Dr. phil.-nat.: Master of Science in Biologywith Major in Cell Biology at the University of Bern in 2003. PhDin Bioinformatics in 2007 with Prof. Pascal Maeser. CurrentlyPostdoc at the ETH Zurich working for SystemsX.