Comparative Toxicogenomics: Volume 2

Klappentext Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. Zusammenfassung Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. This work covers different organisms ranging from humans to model species so researchers can see how the technique has been used in different organisms and compare the results of each. Inhaltsverzeichnis Daphnia Toxicogenomics Joseph R. Shaw, Dartmouth College Human Toxicogenomics Professor Joseph Lunec and Dr. Eugene Halligan, King's College London Metabolomics and Toxicogenomics Jake Bundy and Jeremy Nicholson, Imperial College Model Organisms of Environmental Toxicogenomics (Ecotoxicological model species - Daphnia, fathead minnow and zebrafish) Chris Vulpe, University of California, Berkely Non-model organism Toxicogenomics or Earthworm Toxicogenomics David Spurgeon, CEH Monks Wood Application of Toxicogenomics for study of endocrine disruption in fish Charles Tyler, Exeter Microbial Toxicogenomics Jason Snape, Astra-Zeneca Brixham Enviornmental Laboratories Comparative Toxicogenomics Jonathan Freedman, NIEHS ...

Zusammenfassung
Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. This work covers different organisms ranging from humans to model species so researchers can see how the technique has been used in different organisms and compare the results of each.

Inhalt

Daphnia Toxicogenomics
Joseph R. Shaw, Dartmouth College
Human Toxicogenomics
Professor Joseph Lunec and Dr. Eugene Halligan, King's College London
Metabolomics and Toxicogenomics
Jake Bundy and Jeremy Nicholson, Imperial College
Model Organisms of Environmental Toxicogenomics (Ecotoxicological model species - Daphnia, fathead minnow and zebrafish)
Chris Vulpe, University of California, Berkely
Non-model organism Toxicogenomics or Earthworm Toxicogenomics
David Spurgeon, CEH Monks Wood
Application of Toxicogenomics for study of endocrine disruption in fish
Charles Tyler, Exeter
Microbial Toxicogenomics
Jason Snape, Astra-Zeneca Brixham Enviornmental Laboratories
Comparative Toxicogenomics
Jonathan Freedman, NIEHS