Contribution of hybrid SPECT/CT imaging in hyperparathyroidism

Hybrid metastable technetium-99-labelled methoxyisobutyl isonitrile(99mTc-MIBI) imaging plays an important role in the diagnosis and management of hyperparathyroidism. The aim of this study is to illustrate the value of 99mTc-MIBI single-photon emission computed tomography (SPECT)/computed tomography (CT) compared with planar imaging .This prospective study included 60 patients aged 17 to 92 years, with a sex ratio of 14:1. Planar imaging showed a parathyroid adenoma in 15 cases, was normal in 44 cases, and was suspicious in one case. SPECT/CT showed a parathyroid adenoma in 30 cases, was normal in 26 cases and was suspicious in 4 cases. The two examinations were concordant in 68% of cases. SPECT/CT then showed its superiority, detecting 15 adenomas not detected by planar imaging. It also made it possible to characterize the doubtful fixation observed on planar imaging. In total, SPECT/CT made it possible to accurately locate the pathological gland in 50% of cases. This would allow the surgical procedure to be oriented towards the choice of a minimally invasive surgical technique.

Autorentext

Dorra BEN SELLEM est docteur en médecine et docteur en sciences, Professeur Hospitalo-Universitaire, Université Tunis El Manar. Naima BEN REJEB est doctorante en biophysique, physique médical et imagerie médicale, Université Tunis El Manar. Wiem ARDHAOUI est titulaire d'un mastère de recherche en biophysique, radiophysique et imagerie médicale.