Coronary Graft Failure

Coronary artery bypass surgery has been developed since 1960s to overcome proximal coronary artery disease. Worldwide, the number of patients that are undergoing coronary artery bypass surgery is steadily increasing. Depending on diverse risk factors, one fifth of grafts are occluded at 1 year. For the remaining, graft patency last usually 815 years. This book brings together the main specialists in the field to review the current evidence on epidemiology, pathophysiology, diagnostic, new imaging techniques and specific therapeutic modalities. This volume aims to update a complex subject represented by coronary graft failure. The authors of this monograph are interventional cardiologists, cardiovascular surgeons and research scientists, who will be creating four parts and 71 chapters that are divided in order to give a uniform interpretation of this condition including all aspects of coronary graft failure This book not only provides the most up-to-dated scientific evidence in the field but in a two-step manner. Each chapter is divided into a at a glance part that reflects the basic evidence on the topic, and a full picture part that brings all what the advanced reader should be brought with.

Presents the current knowledge on coronary grafting and graft disease Details the mechanism of coronary graft failure, its pathology and diagnosis Describes the new-generation drug-eluting stents and other treatment options?

Autorentext

Ion C. intoiu , MD, PhD, FESC

Malcolm JohnUnderwood, MB ChB, FRCS (Ed), MD, FRCS (Cth), FCSHK

Stephane Pierre Cook,MD

Hironori Kitabata, MD

Aamer Abbas, MD, FACC

Klappentext

This book evaluates the current state of knowledge regarding coronary graft failure. It reviews how graft failure can be caused by many factors including the complexity of multiple coronary vessel lesions with surgical revascularization, numerous pathogenic mechanisms of arterial or venous graft dysfunction in the presence of other comorbidities (diabetes mellitus, hypertension and dyslipidemia), and the development of intra-graft atherosclerosis process or distally to the graft.

Coronary Graft Failure represents the accumulation of data on pathophysiological mechanisms of maintenance and progression of this pathology, while quantifying of diagnostic methods and the value of each in part for the best approach strategy for planning of recurrent revascularization (redo). It also evaluates the therapeutic solutions available for graft revascularization. As such, it will be a vital reference for all involved in the management of patients undergoing graft restenosis whether interventional or surgical.

Inhalt
Multivessel Disease in the PCI Era. Where is CABG.- CABG - On-pump versus Off-pump Surgery.- Arterial and Venous Grafting in Multiple Lesions.- Total Arterial Myocardial Revascularization.- Complete versus Incomplete myocardial revascularization.- Impact of Endoscopic Harvesting Methods on Graft Patency in CABG.- Minimally Invasive Coronary Artery Bypass Surgery.- Robotically Assisted in Endoscopic Coronary Bypass Surgery.- Early Postoperative Care after CABG.- Coronary Graft Failure Overview.- Early CABG failure.- Progression of coronary disease after CABG.- Coronary Artery Bypass Grafting in Diabetic Patients.- Multivessel Disease, Risk of Graft Failure.- CABG vs PCI in Multilesional Vessel Disease.- Arrhythmias after CABG.- Myocardial Infarction after CABG.- Ischemic Mitral Regurgitation before and after CABG.- Heart Failure after CABG.- Long Term Clinical Outcome Following CABG.- Histological Analysis in Graft Disease.- Endothelial Function in Myocardial Ischemia.- Oxidative Stress in CABG.- Arterial Graft Failure.- Venous Graft Failure.- Competitive Blood Flow and Graft Patency.- Graft Aneurysm.- Postoperative Graft Dysfunction.- Innate Immunity and Graft Disease.- Atherothrombotic Risk Factors and Graft Disease.- Lipid Management and Graft Failure.- Stent Restenosis and Graft Failure.- Multiple Lesions and Graft Failure.- Impact of Cellular Mechanism of Ischemia on CABG Failure.- Activation of Cytokines in Graft Failure.- Coronary Collaterals and Graft Failure.- Anastomotic Configuration Designs and Graft Patency.- Clinical Evaluation.- Standard and Stress Electrocardiogram.- Echocardiography.- Stress Echocardiography Coronary Tomography.- Radionuclide Imaging.- Coronary Tomography.- Imaging of Coronary Bypass Graft.- AngioCT Before & After CABG.- MRI Before & After CABG.- SPECT Before & After CABG.- Quantitative Coronary Angiography.- Intravascular Ultrasound in Graft.- Optical Coherence Tomography Imaging in Graft.- Coronary Endoscopy.- Guidelines Regarding the Revascularization in Patients with Prior CABG.- Strategies in Extending the Life of Saphenous Vein Grafts.- PCI of Saphenous Vein Graft Failure.- PCI Strategy of Coronary By-pass Graft Failure.- Re-operative Surgery.- Management of Heart Failure after CABG.- CRT in Heart Failure post-CABG Patients.- Pretreatment of Excimer Laser Atherectomy for the Saphenous Vein Graft.- PCI with Newer Generation Stents.- PCI with Biodegradable Scaffolds.- PCI for Distal Anastomotic Lesions.- Slow flow-No reflow Phenomena.- The Use of Protection Devices in Vein Graft Intervention.- Stent Restenosis in Coronary Grafts.- Coronary Artery Grafting Following Stent Restenosis.- Stent as a Carrier of Growth Factors or Cytokines for Prevention of Re-stenosis.- Myoblast Transplantation and Adenoviral VEGF-C Transfer in Coronary Artery Disease.- Targeted Therapies for VGD and Restenosis.- The Cardiac Stem Cells Population a new Target for Cardiac Failure.- Gene and Cell Therapies Current Results andPerspective.