Coronary Vasomotion Abnormalities

This book reviews the latest findings on epicardial coronary spasm and coronary microvascular dysfunction (CMD), important diseases for understanding coronary artery vasomotion abnormalities. The book chiefly consists of two major parts, each of which explores the epidemiology, pathophysiology, diagnosis and treatment of the diseases. The chapters present a range of experimental and clinical studies, including the editor's life's work on coronary spasm; how Rho-kinase activation plays an important role in connection with the disease; how chronic adventitial inflammation is a central pathophysiology of the spasm; the importance of Rho-kinase activation in the pathogenesis of CMD; how epicardial spasm and CMD frequently co-exist; and much more. Coronary Vasomotion Abnormalities will help practicing cardiologists, cardiac surgeons, vascular biologists and radiologists understand the latest issues concerning the clinical, interventional, and surgical management of these conditions, and offer these readers valuable insights into the effective treatment of microvascular angina.

Autorentext

Hiroaki Shimokawa, MD, PhD

Professor and Chairman

Department of Cardiovascular Medicine

Tohoku University Graduate School of Medicine

Sendai 980-8574, Japan.

Inhalt

1. Overview.- Part 1. Epicardial Coronary Artery Spasm.- 2. Epidemiology of Vasospastic Angina.- 3. Pathophysiology and Molecular Mechanisms of Coronary Artery Spasm.- 4. Diagnosis of Coronary Artery Spasm.- 5. Treatment of Coronary Artery Spasm.- Part 2. Coronary Microvascular Dysfunction.- 6. Epidemiology of Coronary Microvascular Dysfunction.- 7. Pathophysiology of Coronary Microvascular Dysfunction.- 8. Diagnosis of Coronary Microvascular Dysfunction.- 9. Treatment of Coronary Microvascular Dysfunction.