CtBP Family Proteins

This book is a comprehensive monograph on the CtBP family proteins. These proteins are gaining wide scientific interest due to their critical roles in animal development and in oncogenesis. The CtBP family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. They also perform several diverse cytosolic functions such as Golgi maintenance and in central nervous system synapses.

Contains Chapters authored by experts in various aspects of CtBP family proteins from Drosophila, vertebrates and plants This is a valuable reference source for beginning and established investigators interested in CtBP

Klappentext

When I received an invitation from Ron Landes (Landes Bioscience) to edit a book on CtBP family proteins, I was gratified to realize that the importance of these proteins has reached the level of deserving a 'separate' book. As the reader can see, there has been significant advancement in our understanding of the fijnctions of these proteins in the past ten years since CtBPl was cloned in our laboratory. Genetic and biochemical studies with Drosophila provided the critical evidence to show that dCtBP is a transcriptional CO repressor. Genetic studies with mutant mice have established that these proteins are essential for animal development. The CtBP family proteins are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the mo lecular basis of its dual activity and the interaction with target peptides. The organization of the vertebrate CtBP2 gene has provided a novel example of genomic consolidation indicating how a single gene could code for two di verse proteins. I believe that this book will be a valuable reference source for new researchers to understand more about the CtBP family proteins and their role in growth, development and oncogenesis.

Zusammenfassung
The Ctbp family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. This book is a comprehensive monograph on the Ctbp family proteins.

Inhalt
CtBP Family Proteins.- Transcriptional Repression by the CtBP Corepressor in Drosophila.- CtBP and Hematopoietic Transcriptional Regulators.- CtBP.- The Significance of the CtBP AdE1A Interaction during Viral Infection and Transformation.- CtBP Proteins in Vertebrate Development.- CtBP as a Redox Sensor in Transcriptional Repression.- CtBP Corepressor Complex.- Structural Determinants of CtBP Function.- CtBP 3/BARS and Membrane Fission.- CtBPs as Synaptic Proteins.- A New Member of the CtBP/BARS.